N utrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.Tsang AH, Nuzzaci D, Darwish T, Samudrala H, Blouet C.Mol Metab. Cell Reports, 2021Ĭalcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. W Cheng, I Gonzalez, W Pan, AH Tsang, J Adams, E Ndoka, D Gordian, B Khoury, K Roelofs, S Evers, A MacKinnon, S Wu, H Frikke-Schmidt, JN Flak, JL Trevaskis,CJ Rhodes, S Fukada, RJ Seeley, DA Sandoval, DP Olson, C Blouet, MG MyersJr. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizo T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. We identify druggable targets to manipulate these cells and circuits in obese animals and test the efficiency of these approaches to treat obesity and metabolic diseases.These models are combined with refined neuroendocrine, behavioural and metabolic assessments in behaving animals. We characterise their functions using neuroanatomical and cell-specific inducible and reversible gain- and loss-of-function models (knock-out, DREADDs, neuronal silencing, etc).We determine how these cells and circuits are working in normal physiology and impaired in obesity and metabolic diseases.We map the connectivity of these populations using viral neurotracing approaches.We use molecular genetics and neurosurgery in model organisms to label molecularly- or activity-defined brain cell populations that are engaged during specific nutritional or metabolic contexts.We employ a multi-disciplinary approach to identify and characterise metabolic- and nutrient-sensing cells in the brain, perform discrete molecular manipulations of these cells, and decipher the downstream behavioural, metabolic and neuroendocrine circuits. Our aim is to help characterise these pathways to eventually develop safe and efficient therapies promoting satiety and weight loss. Obesity is a disease of brain pathways regulating appetite and metabolism. Public engagement: young people and schools.Public engagement: festivals and events.PhD Programme for Health Professionals at the Universities of Cambridge and East Anglia.Epigenetic programming of metabolic health across the life course.

Entero-Endocrinology including the effects of Bariatric Surgery.Adipose tissue dysfunction and lipotoxicity.Mechanisms in disorders of energy balance.Developing people – Research operations & support teams.Developing people – Early and mid career investigators.Developing people – Postdoctoral researchers.Equality, Diversity, Inclusion and Wellbeing Committee.Equality, Diversity, Inclusion and Wellbeing.Wellcome-MRC Institute of Metabolic Science

Olson schwartz